C. Gomez

CDK4 or CDK6 upregulation induces DNA replication stress and genomic instability to cause EGFR targeted therapy resistance in lung cancer

This study shows that CDK4/6 upregulation causes DNA replication stress and genomic instability, leading to resistance to EGFR inhibitors in lung cancer, and suggests combining CDK4/6 and EGFR inhibitors as a treatment.

Changes in bird migration phenology over six decades: a perspective from the Neotropical non-breeding grounds

The paper examines changes in bird migration phenology over six decades in Colombia, finding shifts in both spring and fall migration patterns among 12 migratory species.

A focal adhesion kinase-YAP signaling axis drives drug tolerant persister cells and residual disease in lung cancer

This study identifies a FAK-YAP signaling axis that drives drug-tolerant persister cells and residual disease in lung cancer, showing that inhibiting this axis improves tumor response to targeted therapies.

Multi-modal profiling of the extracellular matrix of human fallopian tubes and serous tubal Intraepithelial carcinomas

The paper characterizes the extracellular matrix (ECM) composition in benign fallopian tubes and serous intraepithelial carcinomas (STICs), identifying ECM protein changes associated with STIC formation.

STRESS, an automated geometrical characterization of deformable particles for in vivo measurements of cell and tissue mechanical stresses

The paper introduces STRESS, an automated software to quantify mechanical stresses from microdroplet deformations in 3D multicellular systems, demonstrating its application in zebrafish embryos.

Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

This study shows that targeted cancer therapy induces APOBEC-mediated mutagenesis, promoting drug resistance by increasing genetic diversity through mechanisms involving NF-κB activation and reduced DNA repair.

100+ years of bird survey data reveal changes in functional fingerprints indexing ecosystem health of a tropical montane forest through time

The paper analyzes 100+ years of bird survey data to track changes in the functional fingerprint of a tropical montane forest, revealing shifts in ecosystem health due to species extirpations and additions.

A novel gonorrhea vaccine composed of MetQ lipoprotein formulated with CpG shortens experimental murine infection

This study evaluates a gonorrhea vaccine candidate, rMetQ-CpG, showing it induces protective immune responses and accelerates bacterial clearance in a murine model.

Unveiling Crucivirus Diversity by Mining Metagenomic Data

This study identifies and characterizes 451 new crucivirus genomes and ten CP-encoding elements through metagenomic data analysis, revealing high sequence diversity and frequent recombination.

Cooperate-and-radiate co-evolution between ants and plants

The paper investigates whether mutualistic interactions between ants and plants accelerate diversification in both lineages, finding that ant species associated with plants have higher diversification rates.