Author

S. Moquin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:structural biology· 2 Organism:virus· 2 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. M. Shaqra· 3 shared C. A. Schiffer· 3 shared D. Dovala· 3 shared N. Kurt Yilmaz· 3 shared M. Knapp· 2 shared Q. Y. Huang· 2 shared S. N. Zvornicanin· 2 shared D. Bolon· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersBiochemistry

A. M. Shaqra

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Author profile →

3 papers

Recent·Most cited

Contributions of hyperactive mutations in Mpro from SARS-CoV-2 to drug resistance

J. M. Flynn, S. N. Zvornicanin, A. M. Shaqra, N. Kurt Yilmaz, S. Moquin, D. Dovala, C. A. Schiffer, D. Bolon

This study identifies hyperactive mutations in SARS-CoV-2 Mpro that increase enzyme activity and contribute to drug resistance, finding them more prevalent than binding-reducing mutations.

bioRxiv · Sep 28, 2023 · PreprintBiochemistry

Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses

S. N. Zvornicanin, A. M. Shaqra, Q. Y. Huang, E. Ornelas, M. Moghe, M. Knapp, S. Moquin, D. Dovala, C. A. Schiffer, N. Kurt Yilmaz

The paper determines inhibitor-bound crystal structures of main proteases from delta and gamma coronaviruses to inform structure-based inhibitor design.

bioRxiv · Feb 1, 2023 · PreprintBiochemistry

Defining the Substrate Envelope of SARS-CoV-2 Main Protease to Predict and Avoid Drug Resistance

A. M. Shaqra, S. Zvornicanin, Q. Y. Huang, G. J. Lockbaum, M. Knapp, L. Tandeske, D. T. Barkan, J. Flynn, D. N. Bolon, S. Moquin, D. Dovala, N. Kurt Yilmaz, C. A. Schiffer

This study defines the substrate envelope of SARS-CoV-2 main protease using cocrystal structures to identify vulnerable sites that may lead to drug resistance.

bioRxiv · Jan 25, 2022Biochemistry