Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain
H. Ye, S. Ojelade, D. Li-Kroeger, Z. Zuo, L. Wang, Y. Li, J. Y. J. Gu, U. Tepass, A. A. Rodal, H. J. Bellen, J. M. Shulman
This study shows that Vps29 is essential for retromer function in aging Drosophila brains, affecting synaptic transmission and endolysosomal function through interactions with Rab7 and TBC1D5.
bioRxiv · Oct 1, 2019Cell Biology