H. Ye

Small Extracellular Vesicles from Human Bone Marrow Mesenchymal Stromal Cells enhance migration and regulate gene expression of reparative mechanisms in human dermal fibroblasts

This study compares the effects of sEV and NsEV fractions from hBM-MSCs and NHDFs on fibroblast migration and gene expression, finding sEVs more effective in promoting migration.

Activation of PIEZO1 Inhibits Kidney Cystogenesis

This study shows that activating PIEZO1 reduces cyst formation in kidney cells and ex vivo models, suggesting it could be a therapeutic target for ADPKD.

Engineering PEG10 assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

This paper develops ePAC, a cancer vaccine using PEG10-based virus-like particles to deliver neoantigens and adjuvants, showing efficacy in preclinical models.

Genome-Wide Association Study Reveals Influence of Cell-specific Gene Networks on Soybean Root System Architecture

The paper uses a new root phenotyping system to conduct a GWAS on soybean root system architecture, identifying SNPs and gene networks associated with specific root traits.

Guild-Level Gut Microbial Alterations Associate with Non-hepatitis Virus related Hepatocellular Carcinoma

This study identifies gut microbial alterations associated with non-hepatitis virus related hepatocellular carcinoma using guild-based analysis of microbiome data.

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling

The paper shows that allosteric domain-domain coupling modulates the folding landscape of ABCC transporters, and that folding correctors can rescue misfolding by rewiring these networks.

Androgen receptor inhibition induces metabolic reprogramming and increased reliance on oxidative mitochondrial metabolism in prostate cancer

This study shows that androgen receptor inhibition in prostate cancer cells shifts metabolism to oxidative mitochondrial pathways and increases sensitivity to complex I inhibitors.

ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer

This study identifies ONECUT2 as a master transcription factor that drives resistance in prostate cancer through multiple mechanisms, including activation of neuroendocrine and adenocarcinoma variants, and shows that its inhibition can suppress treatment-resistant lineage plasticity.

A novel taurine-respiring murine gut bacterium contributes to colonization resistance against enteropathogens

The paper identifies and characterizes a new murine gut bacterium, Taurinivorans muris, which uses taurine respiration and contributes to colonization resistance against pathogens.

Natural killer-like B cells promote Th17 cell differentiation and exacerbate rheumatoid arthritis

This study identifies natural killer-like B cells as pathogenic in rheumatoid arthritis by promoting Th17 differentiation and disease severity.

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

The paper identifies a novel binding site on α-tubulin and shows that cevipabulin binding to this site induces tubulin degradation.

A new role of low barrier hydrogen bond in mediating protein stability by small molecules

This study identifies a novel role of low barrier hydrogen bonds in promoting selective tubulin degradation through small molecule interactions.

Empirical abundance distributions are more uneven than expected given their statistical baseline

The paper finds empirical species abundance distributions are more uneven than their statistical baselines, but small communities limit the ability to detect deviations.

Compound FC-10696 Inhibits Egress and Spread of Marburg Virus

The paper identifies FC-10696 as a novel compound that inhibits Marburg virus egress and spread, showing antiviral effects in cell cultures and animal models.

Chemoproteomics Maps Glycolytic Targetome in Cancer Cells

This study maps the glycolytic targetome in cancer cells using TRAP, revealing 913 targets and 2,487 interactions for 10 glycolytic metabolites and their functional roles in cancer biology.

Fast 3D printing of large-scale biocompatible hydrogel models

This paper introduces a fast 3D printing method called FLOAT to create large-scale biocompatible hydrogel models with minimal deformation and cellular injury.

Integrative proteomic and phosphoproteomic analysis of granulosa cells during follicular atresia in porcine

This study identifies differentially expressed proteins and phosphosites in porcine granulosa cells during follicular atresia, revealing potential biomarkers and pathways involved in the process.

Full-length annotation with multi-strategy RNA-seq uncovers transcriptional regulation of lncRNAs in diploid cotton G. arboreum

The paper identifies 9240 lncRNAs in diploid cotton using multi-omics data and reveals their transcriptional regulation and co-expression with protein-coding genes and GWAS SNPs.

Long-term warming weakens stabilizing effects of biodiversity in aquatic ecosystems

The paper examines how long-term warming reduces the stabilizing role of biodiversity in aquatic ecosystems by analyzing time series data and causal relationships.

Male accessory gland factors increased sex pheromone titres in the glands of Spodoptera litura female moths by inhibiting calling behavior

Juvenile hormone regulation on the flight capability of Bactrocera dorsalis (Diptera: Tephritidae)

This study investigates how juvenile hormone (JH) regulates flight capability in Bactrocera dorsalis, finding that JH levels correlate with flight duration and distance, and that JH III treatment enhances flight performance.

MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity

This study shows that MYC down-regulates MEIS1 in prostate cancer, which increases AR activity and HOXB13 expression, promoting tumor development.

Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain

This study shows that Vps29 is essential for retromer function in aging Drosophila brains, affecting synaptic transmission and endolysosomal function through interactions with Rab7 and TBC1D5.

Molecular characterization of carbapenem-resistant Klebsiella pneumoniae isolates with focus on antimicrobial resistance

This study characterizes carbapenem-resistant Klebsiella pneumoniae isolates, identifying ST11 as the main type and blaKPC-2 as the dominant carbapenemase gene.

Targeting EZH2 Increases Therapeutic Efficacy of Check-Point Blockade in Models of Prostate Cancer

This study shows that inhibiting EZH2 enhances the effectiveness of PD-1 checkpoint inhibitors in prostate cancer by increasing PD-L1 expression and immune cell infiltration.

Investigation of the spatial heterogeneity of soil microbial biomass carbon and nitrogen under long-term fertilizations in fluvo-aquic soil

This study investigates how long-term fertilization affects spatial heterogeneity of microbial biomass carbon and nitrogen in fluvo-aquic soil, finding that organic fertilizers reduce variation in microbial biomass but increase spatial variability of MBC.

The intrinsic predictability of ecological time series and its potential to guide forecasting

The paper quantifies intrinsic predictability of ecological time series using permutation entropy and shows its relationship with model forecasting error.