Rapid evolution of Wolbachia genomes in mosquito cell culture
This study tracks short-term Wolbachia genome evolution in mosquito cell culture, identifying mutations linked to bacterial density changes and signs of selective evolution.
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9 papers
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This study tracks short-term Wolbachia genome evolution in mosquito cell culture, identifying mutations linked to bacterial density changes and signs of selective evolution.
C. J. McNamara, T. H. Ant, T. Harvey-Samuel…·S. P. Sinkins
This study shows that expressing cifA and cifB genes from Wolbachia strain wAlbB in Aedes aegypti testes induces CI-like sterility, which can be rescued by maternal cifA expression.
M. V. Mancini, R. Tandavanitj, T. H. Ant…·G. De Lorenzo
This study validates a ZIKV vaccine candidate by testing its efficacy in a mosquito-mouse transmission model, showing protection against disease and reduced viral transmission.
S. Rainey, V. Geoghegan, D. Lefteri…·S. P. Sinkins
This study compares the cellular perturbation and antiviral profiles of Wolbachia strain wAu with other strains, finding unique features in its virus inhibition mechanisms.
M. V. Mancini, T. H. Ant, C. S. Herd…·S. P. Sinkins
This study examines how high temperature cycles affect Wolbachia density and dengue inhibition in two Aedes aegypti strains, showing differences in maternal transmission and virus blocking capacity between wMel and wAlbB.
M. V. Mancini, C. S. Herd, T. H. Ant…·S. P. Sinkins
This study introduces Wolbachia strain wAu into Aedes albopictus, showing it blocks dengue and Zika transmission with minimal fitness cost.
J. K. Herren, L. Mbaisi, E. Mararo…·S. P. Sinkins
This study identifies a Microsporidia symbiont that blocks Plasmodium falciparum transmission in Anopheles arabiensis mosquitoes without affecting mosquito survival or fecundity.
W. A. Nazni, A. A. Hoffmann, A. Noor Afizah…·S. P. Sinkins
The paper describes the release of Aedes aegypti mosquitoes carrying the wAlbB Wolbachia strain in Malaysia to reduce dengue incidence, showing successful establishment and reduced human dengue cases in some areas.
S. J. Rihn, M. A. Aziz, D. G. Stewart…·S. J. Wilson
This study identifies TRIM69 as an interferon-induced gene that potently inhibits VSIV, with specific antiviral activity and evolutionary signatures of positive selection.