Author

S. Pacheco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:development & morphogenesis· 3 Organism:mouse· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. Martinez-Perez· 2 shared I. Roig· 2 shared A. B. Siemer· 1 shared A. Castaner· 1 shared A. L. Jaso-Tamame· 1 shared A. Maldonado-Linares· 1 shared A. Martinez-Marchal· 1 shared A. S. Falk· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersCell Biology

E. Martinez-Perez

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

GRAS-1 is a conserved novel regulator of early meiotic chromosome dynamics in C. elegans

M. Martinez-Garcia, P. Robles, M. W. Skinner, K. A. Baran, S. Nadarajan, N. Shin, C. G. Silva-Garcia, T. T. Saito, S. Beese-Sims, A. Castaner, S. Pacheco, E. Martinez-Perez, P. W. Jordan, M. P. Colaiacovo

This study identifies GRAS-1 as a conserved regulator of early meiotic chromosome dynamics in C. elegans, showing its role in coordinating chromosome movement with cytoskeletal forces.

bioRxiv · Sep 6, 2022 · PreprintCell Biology

Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice

W. J. Mason, D. J. Jafree, G. Pomeranz, M. Kolatsi-Joannou, S. Pacheco, D. A. Moulding, A. Wolf, C. Kupatt, C. Peppiatt-Wildman, E. Papakrivopoulou, P. R. Riley, D. A. Long, E. Vasilopoulou

This study shows that systemic TB4 gene therapy prevents podocyte injury and albuminuria in mice with Adriamycin-induced glomerular disease.

bioRxiv · May 24, 2021Physiology

Structural model of the proline-rich domain of huntingtin exon-1 fibrils

A. S. Falk, J. M. Bravo-Arredondo, J. Varkey, S. Pacheco, L. Ralf, A. B. Siemer

The paper models the conformational dynamics of the proline-rich domain (PRD) of huntingtin exon-1 fibrils using molecular dynamics simulations, validated by experimental data.

Biophysical Journal · Nov 1, 2020Peer-reviewedBiophysics

Reactivation of chromosome signalling induces reversal of the meiotic program

M. Castellano-Pozo, S. Pacheco, G. Sioutas, A. L. Jaso-Tamame, M. H. Dore, E. Martinez-Perez

The paper shows that meiotic progression can be reversed by reactivating chromosome signaling, which re-installs DSB formation and chromosome movement machinery through CHK-2 activity.

bioRxiv · Sep 3, 2019 · PreprintCell Biology

ATR function is indispensable to allow proper mammalian follicle development.

S. Pacheco, M. Garcia Caldes, I. Roig

This study shows that reduced ATR expression causes sterility in mice due to defects in follicular progression, not meiotic recombination.

bioRxiv · Nov 16, 2018Cell Biology

ATR Is Required To Complete Meiotic Recombination In Mice

S. Pacheco, A. Maldonado-Linares, M. Marcet-Ortega, C. Rojas, A. Martinez-Marchal, J. Fuentes-Lazaro, J. Lange, M. Jasin, S. Keeney, O. Fernandez-Capetillo, M. Garcia-Caldes, I. Roig

This study shows ATR is essential for meiotic recombination and prophase completion in mice by promoting RAD51/DMC1 assembly and synapsis.

bioRxiv · May 3, 2017Cell Biology