D. A. Long

A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney disease

The paper identifies a unique pericystic endothelium in ADPKD that contributes to microvascular remodelling and impaired perfusion, suggesting vascular targets for early intervention.

Mapping the blood vasculature in an intact human kidney using hierarchical phase-contrast tomography

This study maps the entire human kidney vasculature using hierarchical phase-contrast tomography, revealing structural differences in vascular architecture across kidney zones.

Three-dimensional imaging and single-cell transcriptomics of the human kidney implicate perturbation of lymphatics in alloimmunity

This study uses 3D imaging and single-cell RNA-sequencing to analyze human kidney lymphatics, revealing structural and transcriptional changes in rejecting kidney transplants.

Exploration of the single-cell transcriptomic landscape identifies aberrant glomerular cell crosstalk in a murine model of WT1 kidney disease

This study uses single-cell RNA sequencing to identify disrupted cell-cell communication in a mouse model of WT1 kidney disease, highlighting non-immunological pathology and suggesting vascular-targeted therapies.

Kidney organoids: A system to study human basement membrane assembly in health and disease

This study uses kidney organoids to investigate basement membrane assembly dynamics, identifying conserved temporal patterns and pathogenic variant effects.

Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice

This study shows that systemic TB4 gene therapy prevents podocyte injury and albuminuria in mice with Adriamycin-induced glomerular disease.

Multiscale three-dimensional imaging of intact human organs down to the cellular scale using hierarchical phase-contrast tomography

This paper introduces HiP-CT, a technique for high-resolution 3D imaging of intact human organs, and demonstrates its application to study structural details of organs and their functional units.