Scorpion α-toxin LqhαIT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels
S. Phulera, C. J. Dickson, C. J. Schwalen, M. Khoshouei, S. J. Cassell, Y. Sun, T. Condos, J. Whicher, W. A. Weihofen
This study determines the cryo-EM structure of LqhIT bound to NavPas, revealing its interaction with a glycan at the pore domain and its mechanism of action.
bioRxiv · Jan 26, 2024Biophysics