Cancer BiologybioRxivPreprint
Loss of E-cadherin Induces IGF1R Activation Revealing a Targetable Pathway in Invasive Lobular Breast Carcinoma
A. Elangovan, J. Hooda, L. Savariau…·A. V. Lee
This study shows that loss of E-cadherin in ILC leads to increased IGF1R activation and sensitivity to inhibitors, suggesting a therapeutic target and biomarker for ILC.
DOI 10.1101/2022.02.22.480917