BiophysicsbioRxiv
Force-dependent stimulation of RNA unwinding by SARS-CoV-2 nsp13 helicase
K. J. Mickolajczyk, P. M. M. Shelton, M. Grasso…·T. M. Kapoor
This study investigates the force-dependent unwinding activity of SARS-CoV-2 nsp13 helicase using optical tweezers, revealing increased unwinding frequency, processivity, and velocity under destabilizing force.
DOI 10.1016/j.bpj.2020.11.2276