Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors
A. L. Casillas, S. S. Chauhan, R. K. Toth…·N. A. Warfel
This study identifies PIM1 kinase as a regulator of HIF-1α stability and angiogenesis in solid tumors through direct phosphorylation at threonine 455.