S. S. Merchant

This study identifies distinct roles of CTR1 and CTR2 in Cu import and mobilization in Chlamydomonas, with CTR1 mediating high-affinity uptake and CTR2 facilitating Cu remobilization under Zn deficiency.

The paper shows that cysteine is an ancestral Cu(I) ligand in Chlamydomonas reinhardtii, as Zn deficiency disrupts Cu homeostasis and increases cysteine levels, which co-localize with Cu in acidocalcisomes.

This study identifies CrATX1 in Chlamydomonas as essential for copper distribution to the secretory pathway and biomass maintenance under conditions requiring cupro-enzyme metabolic pathways.

The paper uses XFM to quantify trace metal storage in Chlamydomonas acidocalcisomes under metal over-accumulation, showing Fe and Cu sequestration and distinct organelle populations.

The paper identifies co-expression relationships in Chlamydomonas reinhardtii genes and highlights batch culture synchronization as a source of variation.