S. S. Satapathy

The paper develops a method to estimate the ti/tv ratio in E. coli coding sequences by accounting for codon degeneracy and pretermination codons, revealing insights into purifying selection.

This study compares polymorphism frequencies between transcribed and untranscribed intergenic regions in E. coli and S. enterica, finding that transcribed regions have lower polymorphism rates due to repair mechanisms and sequence features.

The paper compares synonymous polymorphism in co-transcribed gene pairs in E. coli operons, finding differences in mutation patterns related to codon degeneracy.

The paper modifies the dN/dS ratio calculation to account for transition/transversion rate differences and non-sense substitutions, showing higher dN/dS values in E. coli and S. enterica genes.