Cell BiologybioRxivPreprint
Adaptive fitness in APC-mutant cells requires chromosome rearrangements
Y. Kawasaki, T. Hamaji, K. Owada…·Y. Mimori-Kiyosue
The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.
DOI 10.1101/2020.09.18.303016