B.-C. Chen

Expansion microscopy with trypsin digestion and tyramide signal amplification (TT-ExM) for protein and lipid staining

The paper introduces TT-ExM, an improved expansion microscopy technique that reduces protein loss and enhances fluorescence signals through trypsin digestion and tyramide signal amplification, enabling ultrafine-resolution imaging of cellular structures.

Optogenetic Manipulation of Cell Migration with High Spatiotemporal Resolution Using Lattice Lightsheet Microscopy

This study modifies lattice lightsheet microscopy to enable optogenetic manipulation of cell migration with high spatiotemporal resolution, achieving subcellular control and long-term cell viability.

Dynamin-2 Phosphorylation as A Critical Regulatory Target of Bin1 and GSK3α for Endocytosis in Muscle

This study identifies Bin1 and GSK3α regulation of Dyn2 phosphorylation as critical for endocytosis in muscle, linking it to hereditary myopathy.

Insulin Signaling Attenuates GLUT4 Endocytosis in Muscle Cells via GSK3a-Dyn2-Bin1 Interplay

This study identifies that insulin signaling reduces GLUT4 endocytosis in muscle cells by inhibiting Dyn2 activity through GSK3a-Bin1 interactions.

Adaptive fitness in APC-mutant cells requires chromosome rearrangements

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

PIP3 depletion rescues myoblast fusion defects in human rhabdomyosarcoma cells

This study shows that PIP3 depletion via PTEN rescues myoblast fusion defects in human rhabdomyosarcoma cells by reducing bubbling blebs during differentiation.

Aurora B is required for programmed variations of cytokinesis during morphogenesis in the C. elegans embryo

The paper investigates cytokinesis variations during C. elegans embryonic morphogenesis and finds Aurora B kinase is essential for epithelial polarization and tissue formation.

Three-dimensional actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes

This study uses lattice light sheet microscopy to analyze three-dimensional neutrophil pseudopods, revealing their lamellar structure and role in directional changes.