Cancer BiologybioRxivPreprint
Short-course but not prolonged treatment with ATR inhibitor AZD6738 integrates with radiotherapy to generate a tumor antigen-specific CD8+ T cell expansion in the periphery
F. P. Vendetti, D. A. Clump, S. Schamus-Haynes…·C. J. Bakkenist
The paper shows that short-course ATR inhibitor treatment with radiotherapy enhances CD8+ T cell expansion in draining lymph nodes, while prolonged treatment inhibits this effect.
DOI 10.1101/2022.04.11.487886