Author

A. Bostwick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:metabolomics· 5 Research Focus:metabolism & bioenergetics· 4 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

N. W. Snyder· 6 shared H. Jiang· 3 shared C. Mesaros· 2 shared E. von Krusenstiern· 2 shared J. Liu· 2 shared J. Singh· 2 shared K. E. Wellen· 2 shared K. Huber· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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6 shared papersBiochemistry

N. W. Snyder

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6 papers

Recent·Most cited

Comparison of colorimetric, fluorometric, and liquid chromatography-mass spectrometry assays for acetyl-coenzyme A

D. S. Kantner, E. Megill, A. Bostwick, V. Yang, C. Bekeova, A. Van Scoyk, E. Seifert, M. W. Deininger, N. W. Snyder

The paper compares colorimetric, fluorometric, and LC-MS-based assays for measuring acetyl-CoA, finding that LC-MS/MS and LC-HRMS provide reliable results with internal standards, while colorimetric ELISA fails even with standards.

bioRxiv · Jun 1, 2023Biochemistry

Thymidine rescues ATR kinase inhibition induced deoxyuridine contamination in genomic DNA, cell death, and Type 1 interferon expression

N. Sugitani, F. P. Vendetti, A. J. Cipriano, P. Pandya, J. J. Deppas, T. N. Moiseeva, S. Schamus-Haynes, Y. Wang, D. Palmer, H. U. Osmanbeyoglu, A. Bostwick, N. W. Snyder, Y.-N. Gong, K. M. Aird, G. M. Delgoffe, , C. J. Bakkenist

This study shows that thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination, cell death, and Type 1 interferon expression in CD8+ T cells.

bioRxiv · Feb 24, 2022 · PreprintCancer Biology

Primary saturation of α,β-unsaturated carbonyl containing fatty acids does not abolish electrophilicity

N. W. Snyder, J. O'Brien, B. Singh, G. Buchan, A. D. Arroyo, X. Liu, A. Bostwick, E. L. Varner, A. Angajala, R. W. Sobol, I. A. Blair, C. A. Mesaros, S. G. Wendell

This study investigates the electrophilicity of saturated oxo-fatty acids and finds that mono-saturation retains electrophilicity, while double saturation abolishes it, implicating PTGR1 in their metabolism.

bioRxiv · Sep 24, 2020Biochemistry

Quantitative sub-cellular acyl-CoA analysis reveals distinct nuclear regulation

S. Trefely, K. Huber, J. Liu, M. Noji, S. Stransky, J. Singh, M. Doan, C. D. Lovell, E. von Krusenstiern, H. Jiang, A. Bostwick, H. L. Pepper, L. Izzo, S. Zhao, J. P. Xu, , N. W. Snyder

The paper introduces SILEC-SF, a method for sub-cellular metabolomic analysis, and finds distinct nuclear acyl-CoA profiles with notable propionyl-CoA enrichment and a new metabolic pathway for histone propionylation.

bioRxiv · Jul 30, 2020 · PreprintBiochemistry

Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism

S. Trefely, J. Liu, K. Huber, M. T. Doan, H. Jiang, J. Singh, E. von Krusenstiern, A. Bostwick, P. Xu, J. Bogner-Strauss, K. E. Wellen, N. W. Snyder

The paper corrects for artifactual post-harvest metabolism in subcellular isotope tracing to reveal compartment-specific metabolic kinetics.

bioRxiv · Aug 28, 2019Biochemistry

Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry

R. Kuskovsky, R. Buj, P. Xu, S. Hofbauer, M. T. Doan, H. Jiang, A. Bostwick, C. Mesaros, K. M. Aird, N. W. Snyder

This paper develops a method to simultaneously quantify and trace dNTP metabolites using isotope dilution and high-resolution mass spectrometry, showing improved accuracy and metabolic pathway insights.

bioRxiv · Oct 29, 2018Biochemistry