S. Sieber

Signal Antagonists Suppress Pseudomonas syringae Pathogenicity

This study designs and synthesizes leudiazen analogs that inhibit Pseudomonas syringae virulence without killing the bacteria, reducing resistance risk.

Functional Biosynthetic Stereodivergence in a Gene Cluster via a Dihydrosydnone N-oxide

The paper investigates a gene cluster that produces both enantiomerically pure and racemic metabolites through a stereodivergent pathway involving a dihydrosydnone N-oxide intermediate.

A single Microcoleus species causes benthic cyanotoxic blooms worldwide

The paper identifies a single Microcoleus species, Microcoleus anatoxicus, as the cause of benthic cyanotoxic blooms in multiple regions worldwide.

Global meta-analysis reveals overall benefits of silvopastoral systems for biodiversity

This study conducts a global meta-analysis of silvopastoral systems, finding they enhance biodiversity compared to treeless pastures and perform similarly to forests, with regional and taxonomic variations.

Cyclitol secondary metabolism is a central feature of Burkholderia leaf symbionts

The paper identifies cyclitol secondary metabolism as a key feature of Burkholderia leaf endophytes, suggesting horizontal gene transfer enables stable plant-bacterial associations.

Intra-membrane client recognition potentiates the chaperone functions of Calnexin

This study shows that Calnexin uses its transmembrane domain to recognize and bind misfolded membrane proteins, enhancing its chaperone functions in the ER.

A Volatile Signal Controls Virulence in the Plant Pathogen Pseudomonas syringae pv. syringae and a Strategy for Infection Control in Organic Farming

This study identifies leudiazen as a volatile signal molecule in Pseudomonas syringae pv. syringae that controls virulence and demonstrates KMnO4 treatment as a method to degrade it and prevent plant infection.

Biodegradable harmonophores for targeted high-resolution in vivo tumor imaging

This paper develops biodegradable harmonophores for targeted high-resolution in vivo tumor imaging in zebrafish embryos.

Bone marrow-on-a-chip: Emulating the human bone marrow

This paper describes a bone marrow-on-a-chip model that supports long-term cultivation and differentiation of human hematopoietic stem and progenitor cells, demonstrating its utility for drug testing and transplantation studies.