M. Meyer

optiPRM: A targeted immunopeptidomics LC-MS workflow with ultra-high sensitivity for the detection of mutation-derived tumor neoepitopes from limited input material

The paper introduces optiPRM, a targeted LC-MS workflow that enhances sensitivity for detecting mutation-derived neoepitopes from limited tumor samples.

Proteins differentially expressed between pathogenic and non-pathogenic Entamoeba histolytica clones influence pathogenicity by different mechanisms

This study identifies two genes, ehhp127 and ehmp8-2, differentially expressed between pathogenic and non-pathogenic Entamoeba histolytica clones, showing they influence pathogenicity through distinct mechanisms.

No Transcriptional Compensation for Extreme Gene Dosage Imbalance in Fragmented Bacterial Endosymbionts of Cicadas

The paper shows Hodgkinia endosymbionts of cicadas do not transcriptionally compensate for extreme gene dosage imbalance caused by lineage splitting, and have reduced transcriptional control.

Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection

This study shows intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 by inducing antibodies and reducing viral load and lung damage.

Cyclitol secondary metabolism is a central feature of Burkholderia leaf symbionts

The paper identifies cyclitol secondary metabolism as a key feature of Burkholderia leaf endophytes, suggesting horizontal gene transfer enables stable plant-bacterial associations.

Observation of a single protein by ultrafast X-ray diffraction

The paper demonstrates the first X-ray diffraction pattern from a single protein, Escherichia coli GroEL, showing the feasibility of ultrafast imaging of single proteins.

mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge

This study evaluates mRNA-1273 vaccine efficacy in hamsters, showing reduced pulmonary immune activation and improved disease outcomes after prime-boost vaccination.

Plant provenance affects pollinator network: implications for ecological restoration

This study shows that plant provenance affects pollinator interactions, highlighting the need to consider provenance in ecological restoration projects.

Ancient DNA from Guam and the Peopling of the Pacific

This study analyzes ancient DNA from Guam to determine the origins of the first colonizers of the Mariana Islands and their relationship to Polynesians, finding Philippine ancestry and a link to early Lapita individuals.

Chronic oxytocin-driven alternative splicing of CRFR2α induces anxiety

This study shows chronic oxytocin increases soluble CRFR2, linked to anxiety, while acute oxytocin reduces anxiety via membrane-bound CRFR2.

Denisovan ancestry and population history of early East Asians

The paper analyzes the genome of a 34,000-year-old hominin from Mongolia, showing Denisovan ancestry and gene flow from West Eurasians in early East Asians.

Changing color and intensity of LED lighting across the day impacts on human circadian physiology, sleep, visual comfort and cognitive performance

This study investigates the effects of dynamic LED lighting on circadian physiology, sleep, and cognitive performance, finding that dynamic light reduces evening melatonin suppression and improves sleep latency.

The evolutionary history of Neandertal and Denisovan Y chromosomes

The paper analyzes ancient Y chromosomes from Denisovans and Neandertals, finding they split from a shared lineage around 700 kya, with Neandertal Y chromosomes diverging from modern humans around 370 kya.

Quantitative Proteomics and Phosphoproteomics Supports a Role for Mut9-Like Kinases in Multiple Metabolic and Signaling Pathways in Arabidopsis

The paper uses proteomics and phosphoproteomics to show that Mut9-Like Kinases regulate metabolic and signaling pathways in Arabidopsis by affecting phosphorylation and glucosinolate metabolism.

Nociception testing duringfixed-wing ambulance flights.An interventional pilot study on the effects of flight-related environmental changes on the nociception of healthy volunteers.

This study tests nociception in healthy volunteers during air ambulance flights and finds no systematic effects on pain thresholds or detection.

Agricultural intensification reduces microbial network complexity and the abundance of keystone taxa in roots

The paper examines how different farming systems affect wheat root fungal communities, finding that organic farming supports more complex fungal networks and higher abundance of keystone taxa.

Historical biogeography of the leopard (Panthera pardus) and its extinct Eurasian populations

This study analyzes mitogenome sequences from historical and Late Pleistocene leopard samples to resolve their biogeographic history and find a deep bifurcation between African and Eurasian lineages.

Antibody-based vaccine for tuberculosis: validation in horse foals challenged with the TB-related pathogen Rhodococcus equi

This study validates an antibody-based vaccine against Rhodococcus equi in horse foals, showing complete protection through opsonic antibodies and interferon-gamma release.

Are oceanic fronts ecotones? Seasonal changes along the Subtropical Front show fronts as bacterioplankton transition zones but not diversity hotspots

The paper investigates whether oceanic fronts act as ecotones by analyzing seasonal changes in bacterioplankton communities along the Subtropical Front, finding they are transition zones but not diversity hotspots.