A. Mathew

Signal Antagonists Suppress Pseudomonas syringae Pathogenicity

This study designs and synthesizes leudiazen analogs that inhibit Pseudomonas syringae virulence without killing the bacteria, reducing resistance risk.

Functional Biosynthetic Stereodivergence in a Gene Cluster via a Dihydrosydnone N-oxide

The paper investigates a gene cluster that produces both enantiomerically pure and racemic metabolites through a stereodivergent pathway involving a dihydrosydnone N-oxide intermediate.

Olfactomedin-4+ neutrophils exacerbate intestinal epithelial damage and worsen host survival after Clostridioides difficile infection.

This study identifies OLFM4+ neutrophils as pathogenic determinants of intestinal epithelial damage during Clostridioides difficile infection using single-cell transcriptomics and pre-clinical models.

A comprehensive analysis of immune landscape of Indian triple negative breast cancer

This study identifies three immune subtypes in Indian triple-negative breast cancer patients, showing similarities to Western TNBCs and potential for immunotherapy response.

Platinum chemotherapy induces lymphangiogenesis in cancerous and healthy tissues that can be prevented with adjuvant anti-VEGFR3 therapy

Plant biomechanics and resilience to environmental changes are controlled by specific lignin chemistries in each vascular cell type and morphotype

The paper investigates how specific lignin chemistries in different vascular cell morphotypes affect biomechanics and water conduction, showing that changes in lignin composition alter cell wall properties and resilience to environmental stress.

Antifungal activities of artesunate, chloramphenicol, and cotrimoxazole against Basidiobolus species, the causal agents of gastrointestinal basidiobolomycosis

The paper tests antifungal activities of artesunate, chloramphenicol, and cotrimoxazole against Basidiobolus species and finds synergistic effects when combined with voriconazole.

Priming mycobacterial ESX-secreted protein B to form a channel-like structure

The paper investigates the oligomerization and structural properties of EspB, an ESX-1 substrate, revealing its role in forming a channel-like structure for ESX-1 secretion.

A Volatile Signal Controls Virulence in the Plant Pathogen Pseudomonas syringae pv. syringae and a Strategy for Infection Control in Organic Farming

This study identifies leudiazen as a volatile signal molecule in Pseudomonas syringae pv. syringae that controls virulence and demonstrates KMnO4 treatment as a method to degrade it and prevent plant infection.

Genetic architecture constrains exploitation of siderophore cooperation in Burkholderia cenocepacia

This study shows that genetic linkage prevents cheating in siderophore cooperation in Burkholderia cenocepacia by linking synthesis and receptor genes, and demonstrates that breaking this linkage allows cheaters to exploit the public good.