Author

S. Silas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:host-pathogen & immune response· 2 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

J. Bondy-Denomy· 4 shared H. Carion· 3 shared A. Fossati· 1 shared A. Talaie· 1 shared C. Kokontis· 1 shared D. S. Godinez· 1 shared D. Swaney· 1 shared E. Huiting· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersMicrobiology

J. Bondy-Denomy

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4 papers

Recent·Most cited

Conserved jumbo phage factors required for protein import into a phage nucleus

C. Kokontis, T. A. Klein, S. Silas, J. Bondy-Denomy

The paper identifies conserved phage factors required for protein import into a phage nucleus and characterizes their interactions and roles in selectivity.

bioRxiv · Mar 27, 2024 · PreprintMicrobiology

Activation of programmed cell death and counter-defense functions of phage accessory genes

S. Silas, H. Carion, K. S. Makarova, E. Laderman, D. S. Godinez, M. Johnson, A. Fossati, D. Swaney, M. Bocek, E. V. Koonin, J. Bondy-Denomy

The paper identifies and characterizes phage accessory genes (AGs) that activate host antiviral immunity, including programmed cell death, and explores their evolutionary implications.

bioRxiv · Apr 6, 2023 · PreprintMicrobiology

Translation-dependent downregulation of Cas12a mRNA by an anti-CRISPR protein

N. D. Marino, A. Talaie, H. Carion, M. C. Johnson, Y. Zhang, S. Silas, Y. Li, J. Bondy-Denomy

This study shows that AcrVA2 inhibits Cas12a mRNA translation, reducing its anti-phage activity and enabling specific inhibition of Cas12a orthologs.

bioRxiv · Nov 29, 2022 · PreprintMicrobiology

Bacteriophages antagonize cGAS-like immunity in bacteria

E. Huiting, J. Athukoralage, J. Guan, S. Silas, H. Carion, J. Bondy-Denomy

The paper identifies a phage-encoded antagonist of the bacterial CBASS immunity system, showing it is necessary for phage replication and demonstrating CBASS functions as a natural anti-phage immune system.

bioRxiv · Mar 30, 2022 · PreprintMicrobiology