A. Fossati

Defining the constituents and functions of a lipid-based jumbo phage compartment

The paper identifies a lipid-based compartment in early phage infection that protects phage DNA and supports early transcription and translation.

Activation of programmed cell death and counter-defense functions of phage accessory genes

The paper identifies and characterizes phage accessory genes (AGs) that activate host antiviral immunity, including programmed cell death, and explores their evolutionary implications.

SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage

This study shows SARS-CoV-2 variants of concern have mutations that increase spike cleavage and fusogenic capacity, enhancing viral transmission and cell entry.

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

Mapping specificity, entropy, allosteric changes and substrates in blood proteases by a high-throughput protease screen

The paper introduces a high-throughput proteomic method to profile protease activity and substrate specificity in native conditions, achieving high throughput and accuracy.