I. Artsimovitch

This study investigates how RNA polymerase navigates protein roadblocks in E. coli, showing force-dependent effects and the role of GreA in facilitating passage.

The paper investigates how force and α-C-terminal domains influence RNA polymerase recycling after termination, showing force biases diffusion direction and promoter recognition.

This study identifies Rof as an inhibitor of the transcription termination factor Rho, showing it blocks Rho's activity through structural obstruction and conformational changes.

This study shows that Escherichia coli {rho} forms higher-order oligomers under stress, linking transcription termination to cellular physiology.

This paper reveals how RfaH activates virulence gene expression by transforming its structure and stabilizing paused transcription complexes through interactions with ops hairpins.

This study investigates NMPylation and de-NMPylation of SARS-CoV-2 Nsp9 by the NiRAN domain, showing that Nsp12 NMPylates native Nsp9 and that NiRAN residues are essential for this process.

The paper shows that positive supercoiling helps RNA polymerase bypass LacI-mediated DNA loops in E. coli by reducing pauses and enhancing dissociation of roadblocks.

The paper uses high-throughput magnetic tweezers to study E. coli RNA polymerase dynamics, identifying two long-lived backtrack pause states and showing RNA cleavage governs recovery from deep backtracks.

This study investigates the structural dynamics of RfaH, a bacterial virulence factor, revealing how differential local stability governs its metamorphic fold-switch between autoinhibited and active states.

The paper investigates how ligand binding affects the interaction between riboswitch folding and transcriptional pausing in bacterial RNA polymerase.

This study determines the structural basis of how NusG and RfaH regulate transcript elongation by suppressing backtracking and pausing in bacterial RNA polymerase complexes.

The paper shows RfaH, a transcription factor, binds to a hairpin structure in the non-template DNA strand via a conserved pause sequence, revealing a new mechanism for transcriptional regulation.