Author

S. Sriramkumar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

H. M. O'Hagan· 4 shared K. P. Nephew· 4 shared A. H. Ghobashi· 2 shared R. Sood· 2 shared S. A. Miller· 2 shared T. D. Huntington· 2 shared V. Muralikrishnan· 2 shared W. Wang· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersCancer Biology

H. M. O'Hagan

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5 papers

Recent·Most cited

A novel ALDH1A1 inhibitor blocks platinum-induced senescence and stemness in ovarian cancer

V. Muralikrishnan, F. Fang, T. C. Given, R. Podicheti, M. Chchterbinine, S. Sriramkumar, H. M. O'Hagan, T. D. Hurley, K. P. Nephew

This study identifies a novel ALDH1A1 inhibitor that suppresses chemotherapy-induced senescence and stemness in ovarian cancer stem cells, suggesting its potential for clinical use.

bioRxiv · May 9, 2022Cancer Biology

Platinum-Induced Mitochondrial OXPHOS Contributes to Cancer Stem Cell Enrichment in Ovarian Cancer

S. Sriramkumar, R. Sood, T. D. Huntington, A. H. Ghobashi, W. Wang, K. P. Nephew, H. M. OHagan

This study shows platinum treatment increases mitochondrial activity and OXPHOS in ovarian cancer cells, leading to enrichment of cancer stem cells, which can be blocked by OXPHOS inhibitors.

bioRxiv · Feb 1, 2022Cancer Biology

Combined epigenetic and metabolic inhibition blocks platinum-induced ovarian cancer stem cell enrichment

R. Sood, S. Sriramkumar, V. Muralikrishnan, S. Xiao, W. Wang, C. Hassel, K. P. Nephew, H. M. O'Hagan

This study shows that combining DNMT and NAMPT inhibitors with platinum reduces OCSCs and tumorigenesis in ovarian cancer.

bioRxiv · Mar 18, 2021 · PreprintCancer Biology

Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A is Mediated by Replication Protein A in Ovarian Cancer

S. Sriramkumar, T. D. Matthews, A. H. Ghobashi, S. A. Miller, P. S. VanderVere-Carozza, K. S. Pawelczak, K. P. Nephew, J. J. Turchi, H. M. O'Hagan

This study identifies RING1A-mediated ubiquitination of phosphorylated H2AX at platinum DNA damage sites in ovarian cancer, revealing its role in DNA repair and platinum resistance.

Molecular Cancer Research · Nov 1, 2020Peer-reviewedCancer Biology

LSD1 promotes secretory cell specification to drive BRAF mutant colorectal cancer

S. A. Miller, R. A. Policastro, S. Sriramkumar, T. Lai, T. D. Huntington, C. A. Ladaika, G. E. Zentner, H. M. O'Hagan

The paper identifies LSD1 as a regulator of secretory cell specification in BRAF-mutant colorectal cancer, showing its role in tumor growth and metastasis.

bioRxiv · Sep 25, 2020 · PreprintCancer Biology