F. Fang

Dynamic Single Cell Transcriptomics Defines Kidney FGF23/KL Bioactivity and Novel Segment-Specific Inflammatory Targets

This study uses single-cell transcriptomics to analyze FGF23 bioactivity and identify novel inflammatory targets in the kidney, revealing interactions between FGF23 and TNF/NF-κB pathways.

Matrix Vesicles from Osteoblasts Promote Atherosclerotic Calcification

This study shows osteoblast-derived matrix vesicles (Ost-MVs) contribute to atherosclerotic calcification by being released into circulation and transported to plaques, where they exacerbate calcification through the Ras-Raf-ERK pathway.

New insights into functional divergence and adaptive evolution of uncultured bacteria in anammox community by complete genome-centric analysis

The paper uses long-read sequencing to obtain complete metagenome-assembled genomes of anammox bacteria, revealing functional divergence and adaptive evolution through horizontal gene transfer and mobile genetic elements.

Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2

This study shows that inhibiting HOTAIR and EZH2 reduces ovarian cancer stem cell resistance to platinum chemotherapy and improves survival in vivo.

A novel ALDH1A1 inhibitor blocks platinum-induced senescence and stemness in ovarian cancer

This study identifies a novel ALDH1A1 inhibitor that suppresses chemotherapy-induced senescence and stemness in ovarian cancer stem cells, suggesting its potential for clinical use.

Comprehensive Structure and Functional Adaptations of the Yeast Nuclear Pore Complex

This study presents the structure of the yeast nuclear pore complex using cryo-EM, revealing its functional adaptations and evolutionary links.

Influence of age on functional memory T cell diversity

The paper identifies CD73-expressing memory T cells that decline with age and are functionally distinct, with potential interventions to improve immune memory in older adults.

Recombinant chimpanzee adenovirus AdC7 expressing dimeric tandem-repeat RBD of SARS-CoV-2 spike protein protects mice against COVID-19

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

Recombinant SARS-CoV-2 spike S1-Fc fusion protein induced high levels of neutralizing responses in nonhuman primates

This study shows that a recombinant SARS-CoV-2 S1-Fc fusion protein induces strong neutralizing antibodies in nonhuman primates and can be produced at scale for vaccine development.

Quantitative three-dimensional nondestructive imaging of whole anaerobic ammonium-oxidizing bacteria

This study uses synchrotron soft X-ray nano-computed tomography to quantitatively image the 3D ultrastructure of intact anammox bacteria and explores their shape adaptation to Fe2+.

CsHscB as a novel TLR2 agonist from carcinogenic liver fluke Clonorchis sinensis modulates host immune response

The paper identifies CsHscB from Clonorchis sinensis as a TLR2 agonist that modulates macrophage activation and IL-10 production through TLR2-dependent mechanisms.

Feedback Regulation between Initiation and Maturation Networks Orchestrates the Chromatin Dynamics of Epidermal Lineage Commitment

The paper identifies TFAP2C and p63 as key regulators of epidermal lineage commitment and shows TFAP2C initiates differentiation while p63 drives maturation through chromatin dynamics.