Cancer BiologybioRxiv
RTK-dependent inducible degradation of mutant PI3K alpha drives GDC-0077 (Inavolisib) efficacy
K. Song, K. Edgar, E. Hanan…·L. Friedman
The paper shows that GDC-0077 and taselisib degrade mutant PI3K alpha via HER2-dependent mechanisms, enhancing efficacy in PIK3CA-mutant breast cancer.
DOI 10.1158/2159-8290.cd-21-0072