Author

M. Lamkanfi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. Fossoul· 2 shared C. Paget· 2 shared E. Doz-Deblauwe· 2 shared L. Vande Walle· 2 shared N. Winter· 2 shared A. Hessel· 1 shared A. Murgaski· 1 shared A. Remot· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

A. Fossoul

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Author profile →

4 papers

Recent·Most cited

Neutrophil subsets play dual roles in tuberculosis by producing inflammasome dependent-IL-1β or suppressing T-cells via PD-L1

E. Doz-Deblauwe, B. Bounab, F. Carreras, J. Silverira-Fahel, S. C. Oliveira, M. Lamkanfi, Y. Le Vern, P. GERMON, J. Pichon, F. Kempf, C. Paget, A. Remot, N. Winter

The paper identifies two neutrophil subsets in tuberculosis with opposing roles: one promoting inflammation via IL-1β and another suppressing T-cells via PD-L1.

bioRxiv · Nov 17, 2023 · PreprintImmunology

Caspase-1-driven neutrophil pyroptosis promotes an incomplete NETosis upon Pseudomonas aeruginosa infection

K. Santoni, D. Pericat, M. Pinilla, S. Bagayoko, A. Hessel, S. A. Leon-Ycaza, E. Bellard, S. Mazeres, E. Doz-Deblauwe, N. Winter, C. Paget, J.-P. Girard, C. Cougoule, R. Poincloux, M. Lamkanfi, , R. Planes

This study shows that Pseudomonas aeruginosa induces Caspase-1-dependent pyroptosis in neutrophils, leading to incomplete NETosis and promoting bacterial spread.

bioRxiv · Jun 28, 2021 · PreprintImmunology

Inflammasome- and gasdermin D-independent IL-1β production mobilizes neutrophils to inhibit antitumor immunity

M. Kiss, L. Vande Walle, E. Lebegge, H. Van Damme, A. Murgaski, J. Qian, M. Ehling, S. Pretto, E. Bolli, J. Keirsse, Y. Elkrim, M. S. Martins, A. Fossoul, D. Lambrechts, M. Mazzone, , D. Laoui

This study shows IL-1β promotes tumor progression by mobilizing neutrophils to suppress antitumor immunity, independent of inflammasome and GSDMD.

bioRxiv · Aug 4, 2020Immunology

MCC950/CRID3 potently targets the NACHT domain of wildtype NLRP3 but not disease-associated mutants for inflammasome inhibition

L. Vande Walle, I. B. Stowe, P. Sacha, B. L. Lee, D. Demon, A. Fossoul, F. Van Hauwermeiren, P. H. V. Saavedra, P. Simon, V. Subrt, L. Kostka, C. E. Stivala, V. C. Pham, S. T. Staben, S. Yamazoe, , M. Lamkanfi

This study identifies the NACHT domain of wildtype NLRP3 as the target of MCC950/CRID3, showing it inhibits inflammasome activity but not CAPS-associated mutants.

bioRxiv · May 11, 2019Immunology