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S. V. Himanen

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Cancer Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

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A. Vihervaara· 1 shared C. C. Friedel· 1 shared H. M. Haikala· 1 shared M. Barboric· 1 shared Z. Wang· 1 shared

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2023-2023 · peak 1/yr

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1 shared paperCancer Biology

A. Vihervaara

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Recent·Most cited

Cancer BiologybioRxivMar 21, 2023

Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release

Z. Wang, S. V. Himanen, H. M. Haikala…·M. Barboric

This study shows that inhibiting CDK12 in cancer cells activates P-TEFb, leading to increased dependence on P-TEFb for transcriptional elongation and hypersensitivity to P-TEFb inhibitors.

DOI 10.1093/nar/gkad792

humanbulk RNA-seq

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