Cancer BiologybioRxiv
Phenotypic dissection of epithelial lineages and therapeutic manipulation of differentiation programs in human Adenoid Cystic Carcinomas
S. Viragova, L. Aparicio, J. Zhao…·P. Dalerba
This study identifies cell-surface markers to isolate distinct cell types in ACC, shows myoepithelial-like cells as progenitors of ductal-like cells, and demonstrates RA signaling modulation as a therapeutic strategy.