Cell BiologybioRxiv
HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts
N. H. Pipalia, S. Z. Saad, K. Subramanian…·F. R. Maxfield
This study shows HSP90 inhibitors reduce cholesterol storage in NPC1 mutant fibroblasts by enhancing mutant NPC1 protein delivery to lysosomes.
DOI 10.1016/j.jlr.2021.100114