A. Cross

Decoding mTOR signalling heterogeneity in the tumour microenvironment using multiplexed imaging and graph convolutional networks

The paper uses multiplexed imaging and graph convolutional networks to analyze mTOR signaling heterogeneity in colorectal tumors and its correlation with patient prognosis.

Plasma iron controls neutrophil production and function

The paper shows hypoferremia reduces neutrophil production and alters their function, while increasing NETosis, and suggests targeting hepcidin could modulate innate immunity.

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model.

This study shows that activating HIF signaling reduces SARS-CoV-2 infection and respiratory symptoms in hamsters by decreasing viral RNA and epithelial damage.

Quantitative imaging reveals PI3Kδ inhibition reduces rhinovirus-induced damage of small airway epithelia in ex vivo cultured human precision cut lung slices from COPD patients

HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts

This study shows HSP90 inhibitors reduce cholesterol storage in NPC1 mutant fibroblasts by enhancing mutant NPC1 protein delivery to lysosomes.

CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity

This study identifies CD11c+CD88+CD317+ myeloid cells as key drivers of CNS autoimmunity and shows that targeting these cells with anti-CD317 mAb reduces disease.