B. Arnold

hGRAD - a versatile 'one-fits-all' system for the acute depletion of RNA binding proteins in nuclear condensates

hGRAD rapidly depletes nuclear RNA binding proteins, enabling study of their roles in RNA processing and dynamics.

Stem cell memory EBV-specific T cells control post-transplant lymphoproliferative disease and persist in vivo

This study develops a protocol to expand EBV-specific stem cell memory T cells, showing improved tumor control and persistence in a PTLD model compared to existing ACT methods.

Subclonal somatic copy number alterations emerge and dominate in recurrent osteosarcoma

This study identifies subclonal copy number alterations in relapsed osteosarcoma, showing MYC gain/amplification in treatment-resistant clones and their emergence before chemotherapy.

Altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa define colitis associated with immune checkpoint inhibitors

This study identifies altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa in immune checkpoint inhibitor-associated colitis using single-cell RNA sequencing and other multi-omics approaches.

Pervasive population genomic consequences of genome duplication in Arabidopsis arenosa

This study investigates the population genomic effects of polyploidy in Arabidopsis arenosa, finding subtle yet widespread impacts on evolutionary processes.