S. Rajan

FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion in vitro and in mouse liver

This study shows FITM2 deficiency reduces VLDL triglyceride secretion and causes ER stress and lipid accumulation in liver cells and mice.

Species-specific dynamics may cause deviations from general biogeographical predictions - evidence from a population genomics study of a New Guinean endemic passerine bird family (Melampittidae).

This study uses population genomics to compare two Melampittidae bird species in New Guinea, finding that habitat dependence affects population connectivity in the rare species.

Combined blockade of VEGF, Angiopoietin-2, and PD1 reprograms glioblastoma endothelial cells into quasi-antigen-presenting cells

This study shows that blocking VEGF, Ang2, and PD1 reprograms GBM endothelial cells into quasi-antigen-presenting cells, enhancing anti-tumor responses and controlling edema.

An Inhibitory Function of TRPA1 Channels in TGF-β1-driven Fibroblast to Myofibroblast Differentiation

This study shows TRPA1 channels inhibit TGF-β1-driven fibroblast to myofibroblast differentiation and may protect against pulmonary fibrosis.

Structurally complex osteosarcoma genomes exhibit limited heterogeneity within individual tumors and across evolutionary time

This study analyzes SCNAs in osteosarcoma using single-cell DNA sequencing, finding limited heterogeneity and suggesting early catastrophic events drive genomic complexity.

Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization

This study shows osteosarcoma tumors retain transcriptional heterogeneity during bone and lung colonization despite selective pressures.

Transient receptor vanilloid 4 (TRPV4) channels are essential for alveolar epithelial cell function

This study shows TRPV4 channels protect alveolar epithelial barriers by maintaining AQP-5 and pSP-C expression, preventing edema during ischemia-reperfusion.

Sympatric wren-warblers partition acoustic signal space and song perch height

This study shows sympatric wren-warblers partition acoustic signal space and song perch height to reduce masking interference.

A missense mutation dissociates triglyceride and phospholipid transfer activities in zebrafish and human microsomal triglyceride transfer protein

This study identifies a missense mutation in MTP that separates triglyceride and phospholipid transfer activities, suggesting potential for selective therapeutic targeting of triglyceride transfer in dyslipidemia.