M. Cam

TRAIL-induced cytokine production via NFKB2 pathway promotes neutrophil chemotaxis and immune suppression in triple negative breast cancers

This study shows TRAIL treatment of TNBC cells activates the NFKB2 pathway, leading to cytokine production that enhances neutrophil chemotaxis and immune suppression.

Metastasis-initiating osteosarcoma subpopulations establish paracrine interactions with both lung and tumor cells to create a metastatic niche

This study identifies metastasis-initiating osteosarcoma subpopulations that interact with lung and tumor cells to form a metastatic niche, highlighting tumor-stromal interactions as key drivers of metastasis.

Trabectedin Enhances Oncolytic Virotherapy by Reducing Barriers to Virus Spread and Cytotoxic Immunity in Preclinical Pediatric Bone Sarcoma

This study shows trabectedin enhances oncolytic virotherapy by reducing anti-viral barriers and boosting immune-mediated tumor regression in preclinical models.

The lnc-FANCI-2 intrinsically restricts RAS signaling in HPV16-infected cervical cancer

This study identifies lnc-FANCI-2 as a regulator of RAS signaling in HPV16-infected cervical cancer, showing its role in lesion progression and patient survival.

KSHV promotes oncogenic FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation

This study identifies KSHV ORF57 as a viral RNA-binding protein that stabilizes FOS RNA, inhibits AEN, and transactivates RGS2 to promote AKT phosphorylation during lytic infection.

Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cells

This study identifies fibrosis as a targetable vulnerability in osteosarcoma lung metastasis by showing nintedanib inhibits metastatic progression through anti-fibrotic effects.

A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling

The paper investigates mitochondrial heterogeneity in the liver by combining spatial proteomics and functional analysis, revealing distinct metabolic functions in periportal and pericentral regions.

Genome-wide regulation of KSHV RNA splicing by viral RNA-binding protein ORF57

This study identifies ORF57's role in regulating KSHV RNA splicing, revealing its impact on viral gene expression and immune evasion during lytic infection.

Single-cell RNA Sequencing Reveals Immunosuppressive Myeloid Cell Diversity and Restricted Cytotoxic Effector Cell Trafficking and Activation During Malignant Progression in Glioma

This study uses single-cell RNA sequencing to analyze immune cell changes during glioma progression, identifying immunosuppressive myeloid cell subsets and potential therapeutic targets.

Structurally complex osteosarcoma genomes exhibit limited heterogeneity within individual tumors and across evolutionary time

This study analyzes SCNAs in osteosarcoma using single-cell DNA sequencing, finding limited heterogeneity and suggesting early catastrophic events drive genomic complexity.

TP53 loss initiates chromosomal instability in high-grade serous ovarian cancer

This study shows that TP53 loss in fallopian tube epithelial cells drives chromosomal instability through cell cycle deregulation, without requiring additional mutations.

Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization

This study shows osteosarcoma tumors retain transcriptional heterogeneity during bone and lung colonization despite selective pressures.

Urine single cell RNA-sequencing in focal segmental glomerulosclerosis reveals inflammatory signatures in immune cells and podocytes

This study uses urine single cell RNA-sequencing to identify inflammatory signatures in immune cells and podocytes in FSGS, suggesting potential for non-invasive diagnosis and biomarker discovery.

Expression of HPV oncogenes from a single integration site in cervical cancer cell lines

The paper identifies that HPV oncogenes are expressed from a single integration site in cervical cancer cell lines, revealing mechanisms of viral-host fusion transcript production and their impact on cell growth.

Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models

This paper shows that papillomavirus can be transmitted through blood and cause infections in animal models, suggesting blood transfusion as a potential route for HPV infection and cancer in humans.