BiophysicsbioRxiv
Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulateslipid-dependent channel activity
B. Goretzki, C. Wiedemann, B. A. McCray…·U. A. Hellmich
The paper investigates how disordered regions in TRPV4 modulate channel activity through lipid-dependent interactions and identifies a conserved autoinhibitory patch that regulates PIP2 binding.
DOI 10.1038/s41467-023-39808-4