Author

U. A. Hellmich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Assay:protein structure· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

B. Goretzki· 2 shared C. Wiedemann· 2 shared F. Tebbe· 2 shared T. Schirmeister· 2 shared W. Steinchen· 2 shared A. Axt· 1 shared A. Guskov· 1 shared B. A. McCray· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

B. Goretzki

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Late stages of the Zika virus life cycle are impaired by a selective TRPML2 agonist

K. K. Schwickert, M. Glitscher, D. Bender, R. Murra, K. Schwickert, S. Pfalzgraf, T. Schirmeister, U. A. Hellmich, E. Hildt

This study shows that the TRPML2 agonist ML2-SA1 inhibits late stages of Zika virus replication by affecting genome replication and intracellular cholesterol distribution.

bioRxiv · Feb 1, 2024 · PreprintCell Biology

Legionella pneumophila macrophage infectivity potentiator protein appendage domains modulate protein dynamics and inhibitor binding

C. Wiedemann, J. J. Whittaker, V. H. Perez Carrillo, B. Goretzki, M. Dajka, F. Tebbe, J.-M. Harder, P. Krajczy, B. Joseph, F. Hausch, A. Guskov, U. A. Hellmich

This study investigates the structural and functional roles of appendage domains in Legionella pneumophila MIP proteins, revealing their impact on inhibitor binding and dynamics, and provides structural insights for developing pathogen-specific inhibitors.

bioRxiv · Apr 24, 2023Biophysics

Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulateslipid-dependent channel activity

B. Goretzki, C. Wiedemann, B. A. McCray, S. L. Schaefer, J. Jansen, F. Tebbe, S.-A. Mitrovic, J. Noeth, J. Donohue, C. M. Jeffries, W. Steinchen, F. Stengel, C. J. Sumner, G. Hummer, U. A. Hellmich

The paper investigates how disordered regions in TRPV4 modulate channel activity through lipid-dependent interactions and identifies a conserved autoinhibitory patch that regulates PIP2 binding.

bioRxiv · Dec 21, 2022Biophysics

Structure, interdomain dynamics and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes

P. Johe, E. Jaenicke, H. Neuweiler, T. Schirmeister, C. Kersten, U. A. Hellmich

This study determines the crystal structure of pro-rhodesain, identifies interdomain dynamics, and reveals a pH-dependent autoactivation mechanism in trypanosomal cathepsin L-like proteases.

bioRxiv · Nov 10, 2020Biochemistry

IM30 IDPs form a membrane protective carpet upon super-complex disassembly

B. Junglas, R. Orru, A. Axt, C. Siebenaller, W. Steinchen, J. Heidrich, U. A. Hellmich, N. Hellmann, E. Wolf, S. A. L. Weber, D. Schneider

This study identifies that IM30 forms a membrane-protecting carpet upon super-complex disassembly, revealing a novel mechanism of membrane stabilization by intrinsically disordered proteins.

bioRxiv · Sep 16, 2020Biophysics