Legionella pneumophila macrophage infectivity potentiator protein appendage domains modulate protein dynamics and inhibitor binding
C. Wiedemann, J. J. Whittaker, V. H. Perez Carrillo, B. Goretzki, M. Dajka, F. Tebbe, J.-M. Harder, P. Krajczy, B. Joseph, F. Hausch, A. Guskov, U. A. Hellmich
This study investigates the structural and functional roles of appendage domains in Legionella pneumophila MIP proteins, revealing their impact on inhibitor binding and dynamics, and provides structural insights for developing pathogen-specific inhibitors.
bioRxiv · Apr 24, 2023Biophysics