ImmunologybioRxivPreprint
Comprehensive Functional Self-Antigen Screening to Assess Cross-Reactivity in a Promiscuous Engineered T-cell Receptor
Govinda Sharma, Fei Teng, James W. Round…·Robert A. Holt
The paper uses Tope-seq to identify cross-reactive epitopes in an engineered T-cell receptor that caused off-target toxicity, highlighting the need for comprehensive screening.
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