Author

Govinda Sharma

Canada's Michael Smith Genome Sciences CentreORCID 0000-0002-5675-2637Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Fei TengiD· 2 shared Robert A. HoltiD· 2 shared Chris May· 1 shared Eric YungiD· 1 shared James Round· 1 shared James W. RoundiD· 1 shared Sarania Sivasothy· 1 shared Scott D. BrowniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Fei TengORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintMay 13, 2025

Comprehensive Functional Self-Antigen Screening to Assess Cross-Reactivity in a Promiscuous Engineered T-cell Receptor

Govinda Sharma, Fei Teng, James W. Round…·Robert A. Holt

The paper uses Tope-seq to identify cross-reactive epitopes in an engineered T-cell receptor that caused off-target toxicity, highlighting the need for comprehensive screening.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivNov 20, 2023

A Synthetic Cytotoxic T cell Platform for Rapidly Prototyping TCR Function

Govinda Sharma, James Round, Fei Teng…·Robert A. Holt

This paper introduces a synthetic cytotoxic T cell platform for rapidly prototyping TCR function, demonstrating successful antigen-specific responses and preservation of antigen-presenting cells.

DOI 10.1038/s41698-024-00669-9

humanproteomics

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