Guy A. Rutter

The paper investigates functional heterogeneity and sex-dependent regulation of pancreatic α-cells by neighboring β- and δ-cells using calcium dynamics in mice.

The paper uses AI to analyze pancreatic islet composition in type 1 diabetes, finding age, sex, and region-dependent changes and beta-cell loss with reciprocal cell expansion.

This study investigates the human Glp1r A316T variant's effects on glucose metabolism and GLP-1RA responses using mouse models and structural analyses.

This study identifies MTFP1 as critical for β-cell mitochondrial structure and function, essential for insulin secretion and glucose homeostasis, and shows its role as a downstream effector of miR-125b.

This study investigates the role of ER calcium stores in glucose-induced Ca2+ waves and intercellular connectivity in mouse pancreatic islets, finding that ER mobilization is insufficient to initiate waves but required for sustained waves and connectivity.

This paper uses a BRET-based high-throughput screen to identify FDA-approved drugs that disrupt 14-3-3{zeta}BAD interactions, showing potential for colorectal cancer treatment.

This paper describes the synthesis and properties of a novel dual GLP-1R/GIPR agonist, HISHS-2001, showing improved pharmacological profile compared to tirzepatide in vitro and in vivo.

This study identifies LONP1's role in mitochondrial protein folding and shows its impact on beta cell survival and hyperglycemia in type 2 diabetes.

This study investigates the effects of SGLT2 inhibition or deletion on corticosterone secretion and cytokine levels in high-fat-fed mice, revealing links between SGLT2 activity, immune modulation, and metabolic homeostasis.

This study shows that de novo ceramide synthesis in beta-cells is essential for normal insulin production and glucose tolerance, as its inhibition leads to reduced beta-cell mass and impaired glucose regulation.

This study monitors beta cell function in vivo over time, showing hyperglycemia disrupts Ca2+ dynamics and hub cells, while GLP1R agonism restores them.

The paper introduces a hierarchical transformer model to detect genetic block interactions, showing improved performance over traditional methods in simulation and UK Biobank data.

This paper investigates sex-dependent effects of dorzagliatin and incretin on insulin secretion in a novel GCK-MODY mouse model, finding additive benefits in males but not females.

This study shows that LKB1 deletion in mouse pancreatic beta cells causes widespread chromatin accessibility changes and affects gene expression, including neuronal genes.

This study shows proinflammatory cytokines suppress NMD activity in β-cells by downregulating UPF3B, leading to increased alternative splicing and ECM-related gene expression, which contributes to β-cell dysfunction.

This study investigates the role of sorcin in hypothalamic ER stress and obesity in mice, finding no significant effects on ER stress, body weight, or food intake.

This study identifies miR-125b-5p as a glucose-regulated miRNA that negatively regulates β-cell function by modulating organelle dynamics and insulin secretion.

This paper shows that deleting Mfn1 and Mfn2 in beta cells impairs mitochondrial structure and insulin secretion, but incretins can partially compensate through EPAC2 signaling.

This study investigates the role of C2cd4b in murine glucose homeostasis, revealing sexually dimorphic effects on body weight and glucose tolerance.

This study identifies DRP1-mediated mitochondrial dynamics as a regulator of apoptotic response during embryonic differentiation in mouse cells.

The paper shows that a loss-of-function variant in ZnT8 improves insulin secretion and protects against type 2 diabetes by enhancing glucose responsiveness and proinsulin conversion.

This study identifies miR-7-mediated repression of Brg1 as a driver of β-cell dedifferentiation through EMT, leading to fibrosis and impaired glucose tolerance in diabetes.