Si-Yang Zheng

This paper develops an interstitium-mimicking alveolar membrane for lung-on-chip systems that enables physiologic aerosol transport and reveals distinct acute-chronic lung injury responses.

The paper introduces PreTIC, a method for single-cell DNA methylation sequencing compatible with droplet microfluidics, and demonstrates its ability to generate over 13,000 methylomes from human cells.

This paper introduces a membrane-free alveoli-on-a-chip using biodegradable scaffolds that mimics interstitial mechanics, immune trafficking, and aerosolized mRNA delivery in human alveoli.

This study shows that mitochondria-containing large extracellular vesicles (lEVs) improve mitochondrial function in heat-stressed neurons and deliver mitochondria to motor neurons in vivo.