Steven S. Hou

The paper introduces a shallow-angle cannula for repeated drug delivery and in vivo imaging in mice, demonstrating its use for tracking degenerating neurons and measuring brain oxygen levels.

This study records γ-secretase activity in living mouse brains using a NIR biosensor and microscopy, revealing cell non-autonomous regulation of the enzyme.

The paper investigates firing rate changes in inhibitory interneurons near amyloid plaques in an Alzheimer's mouse model, finding hyperactivity in somatostatin-expressing interneurons and hypoactivity in parvalbumin-expressing interneurons.

The paper uses real-time imaging to show increased mitochondrial oxidative stress in neurons near Aβ plaques in a mouse model of Alzheimer's disease, and demonstrates that this stress can be reduced by targeting calcium influx or using antioxidants.