Pharmacology & ToxicologybioRxivPreprint
A stapled peptide inhibitor of MDM2 enables pharmacological activation of p53 in zebrafish
Sania Kheder, Martin Krkoška, Filip Mihalič…·Pavitra Kannan
The paper demonstrates that sulanemadlin, a stapled peptide inhibitor of MDM2, specifically activates p53 in zebrafish without inducing apoptosis, enabling direct in vivo studies of p53 regulation.
DOI 10.64898/2026.03.26.714438