Svenja Leible

This study identifies Cph as a key regulator of intestinal stem cell proliferation and differentiation, showing its role in maintaining ISC and EE populations and remodeling progenitor transcriptomes.

This paper introduces scPT-seq, a method to detect CRISPR mutations and transcriptional responses at single-cell resolution in vivo, revealing clonal markers and lineage dynamics in Drosophila intestine.

This study identifies Rab35 as a tumor suppressor that modulates Wnt signaling through a GTPase relay, highlighting its role in restraining intestinal tumorigenesis.

This study develops and benchmarks glyoxal as a fixative for scRNA-seq, showing it preserves transcriptomes in Drosophila and human cells with high correlation to unfixed samples.

The paper develops a new method for analyzing scRNA-seq data based on gene expression correlations to generate a gene expression atlas of the Drosophila wing disc, identifying 824 genes with spatially restricted expression patterns.

The paper describes a sort-and-sequence experiment to identify TOR regulators by selecting flies for wing length, finding novel regulators and parameters to improve experimental reliability.