Cell BiologyJournal of Cell SciencePeer-reviewed
The Drosophila Tumour Suppressor Lgl and Vap33 activate the Hippo pathway by a dual mechanism, involving RtGEF/Git/Arf79F and inhibition of the V-ATPase.
Marta Portela, Swastik Mukherjee, Sayantanee Paul…·Helena E. Richardson
This study shows Lgl activates the Hippo pathway via Vap33 through two mechanisms: interacting with RtGEF/Git/Arf79F and inhibiting V-ATPase activity.