BioengineeringbioRxiv
Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment.
T. A. Tockary, S. Abbasi, M. Masai…·S. Uchida
This paper develops an mRNA vaccine platform that integrates immunostimulatory dsRNA into antigen-encoding mRNA to enhance cancer immunotherapy, showing effective activation of dendritic cells and therapeutic effects in mouse models.