S. Uchida

Comprehensive gene expression analysis of organoid-derived healthy human colonic epithelium and cancer cell line by stimulated with live probiotic bacteria

The paper compares gene expression in healthy human colonic organoid cells and cancer cell lines after coculture with probiotic bacteria, identifying distinct gene signatures and functional changes.

Precise immunofluorescence canceling for highly multiplexed imaging capturing specific cell state

The paper introduces PECAbs for high-specificity multiplexed imaging of cell states and combines them with seq-smFISH to classify cells and identify signal activation states in human tissue.

mRNA vaccine induces protective immunity against the type III secretory virulence of Pseudomonas aeruginosa

This study develops an mRNA vaccine targeting Pseudomonas aeruginosa's type III secretion system, showing improved mouse survival and reduced lung bacterial load after challenge.

Jet injection potentiates naked mRNA SARS-CoV-2 vaccine in mice and non-human primates by adding physical stress to the skin

This study shows that jet injection improves naked mRNA vaccine efficacy in mice and non-human primates by enhancing delivery and immune response without systemic inflammation.

Aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk

This study identifies miR-145-5p as a key regulator of aortic valve calcification through EV-mediated crosstalk, showing it suppresses ZEB2 to enhance ALPL expression and promote calcification in valvular interstitial cells.

Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment.

This paper develops an mRNA vaccine platform that integrates immunostimulatory dsRNA into antigen-encoding mRNA to enhance cancer immunotherapy, showing effective activation of dendritic cells and therapeutic effects in mouse models.

Biomarkers Of Cardiovascular Toxicity Of Benzene Inhalation In Mice

This study investigates the cardiovascular toxicity of benzene inhalation in mice, finding increased endothelial microparticles and platelet-leukocyte aggregates as biomarkers of toxicity.

Genome-wide cis-decoding for expression designing in tomato using cistrome data and explainable deep learning

This study uses cistrome data and explainable deep learning to predict tomato fruit expression patterns from DNA sequences, identifying key regulatory elements involved in ripening.