Cardiomyocyte alpha-1A adrenergic receptors mitigate post-infarct remodeling and mortality by constraining necroptosis
J. Zhang, P. B. Sandroni, W. Huang, L. Oswalt, A. J. Smith, T. Ash, S.-H. Lee, Y.-Y. I. Shih, H.-Y. S. Huang, B.-E. Myagmar, J. C. Schisler, B. C. Jensen
This study shows that cardiomyocyte alpha-1A adrenergic receptors reduce post-infarct mortality and remodeling by limiting necroptosis, with clinical evidence linking beta-blocker use to increased MI mortality.
bioRxiv · Aug 29, 2022 · PreprintPathology