Cancer BiologybioRxiv
PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma
R. J. Duchatel, E. R. Jackson, S. G. Parackal…·M. D. Dun
This study identifies PI3K/mTOR as a targetable genetic dependency in DIPG and demonstrates that combining paxalisib with metformin improves survival in xenograft models.
DOI 10.1172/jci170329