T. Bhardwaj

Curcumin Inhibits Zika Virus NS3 Helicase Activity

This study investigates curcumin's inhibitory effect on ZIKV NS3 helicase activity, finding it interacts with the enzyme and inhibits NTPase activity with an IC50 of 64.42 μM.

Met58 and di-acidic motif located at C-terminal region of SARS-CoV-2 ORF6 plays a crucial role in its structural conformations

The paper investigates the structural dynamics of the C-terminal region of SARS-CoV-2 ORF6, identifying key residues like Met58 and di-acidic motifs that influence its structural conformations and functional properties.

The aggregation potential of Zika virus proteome

This study identifies aggregation-prone regions in the Zika virus proteome using computational tools and experimental validation, showing several viral proteins can form amyloid-like fibrils.

Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal

The paper investigates the binding of the FDA-approved drug Mitoxantrone dihydrochloride to the C-terminal region of SARS-CoV-2 NSP1 and suggests potential therapeutic implications.

Investigating the conformational dynamics of Zika virus NS4B protein

This study investigates the conformational dynamics of Zika virus NS4B protein using molecular dynamics simulations and experiments, identifying the cytosolic region as intrinsically disordered and showing its dynamic behavior under different conditions.

Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes

This study investigates protein aggregation in SARS-CoV and SARS-CoV-2 proteomes, finding that several SARS-CoV-2 proteins form cytotoxic aggregates via a nucleation-dependent mechanism.

Conformational Dynamics of NSP11 Peptide of SARS-CoV-2 Under Membrane Mimetics and Different Solvent Conditions

This study investigates the conformational dynamics of SARS-CoV-2 nsp11 peptide under different membrane mimetics and solvent conditions, revealing its disordered nature and helical propensity in specific environments.